Transphrenia is a mental illness of transgenders and is a form of dementia (a group of psycho-internally [that is, within a person] unstoppable [by the person with the symptoms] thinking and social symptoms that interferes with daily functioning).  This interference takes a range of forms; for example, from desiring to have one’s sexual organs removed to having one’s sexual organs removed.  The key feature of transphrenia is lack of a faculty of moral judgment.  For example:

A man desires to have his sexual organs removed and sees no harm and no evil in the idea of having his sexual organs removed.

Note that if severe symptoms (like having one’s sexual organs removed) are psycho-internally (that is, within a person) stoppable (by the person with the severe symptoms) then the person is not suffering from severe transphrenia.  In this case, if extreme acts, like having one’s sexual organs removed, are committed, the transphrenic person is also a wicked, vile human being.